The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships. OBJECTIVE: The duration of untreated psychosis may influence response to treatment, reflecting a potentially malleable progressive pathological process.The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships. This presentation was delivered by Jo Smith at the Worcestershire Early Intervention Service Study day, 9th June 2011. U2 - 10.1001/archpsyc.62.9.975. Longer DUP has been associated with poorer prognosis (see the DUP and outcomes topic). 2 Accumulating studies have shown that a longer DUP is associated with poorer outcomes for people with first-episode psychosis (FEP), … Figure 1 shows the differences in access to mental 2 The Canadian Journal of Psychiatry -To reduce duration of untreated psychosis (DUP), which has been associated with worse outcomes … Some have suggested that minority ethnic groups have longer treatment delays, and this could lead to worse outcomes. OBJECTIVE The duration of untreated psychosis may influence response to treatment, reflecting a potentially malleable progressive pathological process. follow-ups of ten years or more) are somewhat limited. For over a decade, the DUP has been studied as a potential predictor of a variety of outcomes. AB - Duration of untreated psychosis (DUP) is the time from manifestation of the first psychotic symptom to initiation of adequate treatment. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q Does duration of untreated psychosis affect outcome for people with first episode psychosis? Yet, it is unclear whether a longer DUP causes worse outcomes or whether reported associations have alternative explanations. AIMS To analyse the associations between DUP and long-term outcomes of schizophrenia. Association between duration of untreated psychosis and in cohorts of first-episode outcome patients: a systematic review. 1. To assess the impact of duration of untreated psychosis (DUP) on baseline and 18-month follow-up characteristics controlling for relevant confounders in an epidemiological first-episode psychosis (FEP) cohort.The Early Psychosis Prevention and Am J Psychiatry. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Duration of untreated psychosis predicts functional and clinical outcome in children and adolescents with first-episode psychosis: A 2-year longitudinal study Two influential meta-analyses have established that duration of untreated psychosis (DUP), the time between the onset of psychosis and initiation of appropriate treatment, is correlated with poor outcome (Marshall et al., 2005; Perkins et al., 2005). It has been postulated that a longer DUP leads to a poorer prognosis. Methodologically sound studies that have examined the association of DUP and outcome of schizophrenia in these countries are lacking. 1 One key strategy is reducing the duration of untreated psychosis (DUP), the time from the first symptom of psychosis to the start of treatment. Previous studies have associated a longer DUP with a poor prognosis, but few of them were performed in countries with low and middle level of income. We searched electronic databases and conducted forward … What is the duration of untreated psychosis (DUP)? Arch Gen Psychiatry 2005;62:975–83. This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. Untreated psychosis has long been associated with worse clinical outcomes in patients with schizophrenia. Association Between Duration of Untreated Psychosis and Outcome in Cohorts of First-Episode Patients: A Systematic Review October 2005 Archives of General Psychiatry 62(9):975-83 If so, outcome might be improved through earlier detection and treatment. Objective: The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. Duration of untreated psychosis (DUP) is one of the few potentially modifiable outcome predictors in psychosis. We systematically reviewed the literature on racial and ethnic differences in DUP in patients with FEP. “Larger longitudinal studies of longer duration are needed to examine the association between [duration of untreated psychosis], hippocampal volume and clinical outcomes.” – by Savannah Demko est association between DUP and outcome, which sup-ports the case for clinical trials that examine the effect of reducing DUP. Download Duration of Untreated Psychosis (DUP) Measurement by Jo Smith. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis - Volume 205 Issue 2 - Matti Penttilä, Erika Jääskeläinen, Noora Hirvonen, Matti Isohanni, Jouko Miettunen Studies have shown that the earlier treatment is initiated for psychosis, the better the long-term outcomes for the patient. The duration of untreated psychosis, or DUP, is measured as the time from the beginning of psychotic symptoms to the time a person starts treatment for those symptoms or a diagnosed condition. Duration of untreated psychosis (DUP) is the time between onset of psychotic symptoms and initiation of antipsychotic medication. DUP is also known to be longer in lower- and middle-income countries. by Marshall and colleagues (2) of DUP and outcomes among patients with FEP. Duration of Untreated Psychosis (DUP) is commonly defined as the time interval between onset of definite positive psychotic symptoms and first appropriate treatment. Duration of untreated psychosis has a significant effect on treatment adherence in the initial recovery phase. sociation between shorter duration of untreated psy-chosis and better outcome at follow-up. Perkins DO, Gu H, Boteva K, et al. (Original Article, Report) by "Shanghai Archives of Psychiatry"; Psychology and mental health Schizophrenia Care and treatment Patient outcomes Psychosis is one of the most debilitating psychiatric conditions with limited options to improve outcomes. AIM: Duration of untreated psychosis (DUP) is considered as a key prognostic variable in psychosis. The implementation guideline recommends: 14 to 35 year age entry criteria; First three years of psychotic illness; Aim to reduce the duration of untreated psychosis to less than 3 months BACKGROUND Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Duration of untreated psychosis and outcomes What is duration of untreated psychosis (DUP)? A: The length of time between the start of psychotic symptoms and the beginning of treatment is called the duration of untreated psychosis or DUP. DUP is generally determined as the time from the onset of psychotic symptoms to the initiation of treatment or first clinical presentation, when a diagnosis of first-episode psychosis may be given. There is a requirement for services to reduce the duration of untreated psychosis, as this has been shown to be associated with better long-term outcomes. An extended duration of untreated psychosis (DUP) is associated with poor outcome in first-episode psychosis (FEP). Bradford DW, Perkins DO, Lieberman JA. 45 Studies, primarily performed in high-income countries in which the duration of untreated psychosis is usually less than 5 years, have reported that a longer duration of untreated psychosis is associated with more severe positive and negative symptoms and lower rates of … Duration of untreated psychosis (DUP), defined as delay in treatment with antipsychotic medication, was found to be associated with an unfavorable course of schizophrenia. 2. 2005;62:975-983 URATION OF UNTREATED psychosis (DUP) is de-fined as the time from manifestationofthefirst psychotic symptom to initiation of adequate antipsychotic drug treatment. D Arch Gen Psychiatry. This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. 2005;162(10):1785-1804. Context : Longer duration of untreated psychosis (DUP) is known to be associated with poorer outcome of schizophrenia. Delay in intensive psychosocial treatment (DIPT) may also be related to outcome. DUP is generally determined as the time from the onset of psychotic symptoms to the initiation of treatment or first clinical presentation, when a diagnosis of first-episode psychosis may be given. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. The purpose of this study was to determine whether the dynamics of long-term treatment outcomes in the 12-year follow-up (1997–2000) in patients suffering from schizophrenia are dependent on the duration of untreated psychosis (DUP). DO - 10.1001/archpsyc.62.9.975 This study by Addington et al provides another substantial advance in the burgeoning literature on the importance of the duration of untreated psychosis (DUP) in relation to outcomes in the early course of schizophrenia. Pharmacological management of first-episode schizophrenia and related nonaffective psychoses. The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. METHODS: Data from 2 cohorts of patients with first episode psychosis … Free Online Library: Duration of untreated psychosis and clinical outcomes of first-episode schizophrenia: a 4-year follow-up study. Marshall M, Lewis S, Lockwood A, et al . 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